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Dextroamphetamine is a central nervous system (CNS) stimulant and amphetamine enantiomer that is prescribed for the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. Dextroamphetamine is also used as an athletic performance enhancer and cognitive enhancer, and recreationally as an aphrodisiac and euphoriant. It is a schedule II controlled substance in the United States, Canada, and Europe.
Dextroamphetamine was first synthesized in 1887 by Romanian chemist Lazăr Edeleanu, who named it amidopyrine. In 1903, German psychologist Emil Kraepelin began using dextroamphetamine to treat patients with psychiatric disorders including depression, schizophrenia, alcoholism, and opioid addiction. In the 1920s and 1930s, dextroamphetamine was widely used to treat a variety of medical conditions including obesity, narcolepsy, hay fever, asthma, coughs, bronchitis, and sinusitis. It was also used recreationally during this time.
In 1937, the United States Food and Drug Administration (FDA) approved dextroamphetamine for the treatment of ADHD under the brand name Dexedrine. In the 1950s and 1960s, dextroamphetamine became increasingly popular for use as a cognitive enhancer among college students and professionals seeking to improve their academic performance or job productivity. Dextroamphetamine's popularity as a study drug or "smart drug" declined in the 1970s after reports of abuse emerged.
Dextroamphetamine is still prescribed for ADHD and narcolepsy today; however its use has been largely replaced by other more potent CNS stimulants such as methylphenidate (Ritalin) and Adderall. Dextroamphetamine is also used off-label for the treatment of weight loss in obese individuals who have failed to lose weight through diet and exercise alone. Recreational use of dextroamphetamine remains common despite its potential for dependence and serious adverse effects such as psychosis or cardiovascular events.
Is Dextroamphetamine an agonist or antagonist?
It is also used as an athletic performance enhancer and cognitive enhancer, and has been detected in a number of dietary supplements. Dextroamphetamine is considered to be a Schedule II controlled substance in the United States with a high potential for abuse and dependence. Dextroamphetamine exerts its effects by increasing the levels of dopamine, norepinephrine, and serotonin in the brain. These neurotransmitters are involved in regulating mood, energy, and attention. Dextroamphetamine increases dopamine levels by binding to and stimulating the release of dopamine from nerve endings in the brain. Norepinephrine levels are increased by dextroamphetamine through both release from nerve endings and inhibition of reuptake into neurons. Serotonin levels are also increased by dextroamphetamine, but the mechanism is not well understood. The CNS effects of dextroamphetamine include increased alertness, wakefulness, focus, and motivation; euphoria; decreased appetite; increased heart rate; increased blood pressure; dilated pupils; and suppressed fatigue. These effects can be beneficial for individuals with ADHD or narcolepsy, as they can help to improve concentration and focus while reducing daytime sleepiness or fatigue. However, these same effects can also lead to abuse of dextroamphetamine by people seeking to experience its pleasurable effects or enhance their performance at work or school. Some of the adverse effects associated with dextroamphetamine use include anxiety, agitation, irritability, dizziness, headache, dry mouth, insomnia, loss of appetite, nausea/vomiting , sweating ,and palpitations . Dextroamphetamine use can also lead to psychotic symptoms such as paranoia , delusions ,and hallucinations . Long-term abuse of dextroamphetamine can result in tolerance , dependence ,and addiction . Dextroamphetamine exists as two stereoisomers: levoamphetamines (the more active enantiomer) and dextroamphetamines (the less active enantiomer). Dextroamphetamine is thought to produce its therapeutic effect primarily through activation of dopaminergic systems while levoamphetamines additionally block norepinephrine reuptake . The relative contribution of each enantiomer to the overall pharmacologic effect of mixed amphetamine salts has not been fully elucidated but it is thought that equal amountsof each enantiomer produce similar pharmacologic activity . In general, however, it appears that dextrorotatory stereoisomers are more potent than levorotatory stereoisomers at stimulating dopamine release while levorotatory stereoisomers have greater affinity for norepinephrine transporter sites .
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Do Dextroamphetamine cause long term damage?
It is used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy, and is sometimes prescribed off-label for depression, weight loss, and cognitive enhancement. While dextroamphetamine is considered safe and effective when used as directed, there is a potential for abuse and addiction. When misused or abused, dextroamphetamine can cause serious side effects, including: - Cardiovascular problems (e.g., irregular heartbeat, high blood pressure) - Gastrointestinal problems (e.g., abdominal pain, diarrhea) - Nervous system problems (e.g., insomnia, anxiety, paranoia) - Psychiatric problems (e.g., psychosis, aggression)
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Can Dextroamphetamine make you gain weight?
The exact mechanism by which this happens is not fully understood, but it is thought that the drug affects brain chemistry in a way that promotes appetite and calorie intake. In addition, dextroamphetamine can also cause changes in metabolism that make it more difficult to burn off calories. For these reasons, people who are taking dextroamphetamine should be monitored closely for any signs of weight gain. If you are concerned about gaining weight while on this medication, talk to your doctor or pharmacist about ways to prevent or manage it.
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Is Dextroamphetamine an agonist or antagonist?
It is also known to be an agonist at the trace amine-associated receptor 1 (TAAR1). Dextroamphetamine is used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy. It is also sometimes used off-label as a cognitive enhancer. The exact mechanism of action of dextroamphetamine is not fully understood, but it is thought to work by increasing the release of neurotransmitters dopamine and norepinephrine in the brain. These neurotransmitters are known to play important roles in cognition, focus, and motivation. Dextroamphetamine also inhibits the reuptake of dopamine and norepinephrine into neurons, which further increases their levels in the brain. Dextroamphetamine has both Stimulant and Euphoric effects. The stimulant effects of dextroamphetamine include increased alertness, wakefulness, improved mood, increased energy levels, and improved focus and concentration. The euphoric effects of dextroamphetamine include feelings of pleasure, happiness, and increased confidence. At therapeutic doses, dextroamphetamine is generally considered to be safe with few serious side effects. Common side effects include dry mouth, loss of appetite, insomnia, anxiety, irritability, headache, dizziness, and nausea. However, at higher doses or with abuse potentiality there is a greater risk for more serious side effects such as cardiovascular problems (e.g., high blood pressure), psychiatric problems (e.g., mania), seizure activity, and death.
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How long does it take to come off Dextroamphetamine?
It typically takes anywhere from a few days to a week for the majority of the drug to be out of one's system. However, because Dextroamphetamine is a central nervous system stimulant, it can cause withdrawal symptoms that may last for weeks or even months in some cases. The best way to taper off of Dextroamphetamine is to work with a medical professional who can help you slowly reduce your dosage over time.
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What is a drug called Dextroamphetamine?
It increases alertness, energy, and metabolism while also decreases appetite. Dextroamphetamine is the active ingredient in ADHD medications such as Adderall, Dexedrine, and Vyvanse. It can be addictive if misused.
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Why Dextroamphetamine is dangerous?
It affects chemicals in the brain and nerves that contribute to hyperactivity and impulse control. Dextroamphetamine is used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy. Dextroamphetamine may also be used for purposes not listed in this medication guide. You should not use dextroamphetamine if you are allergic to it, or if you have: severe anxiety or agitation (stimulant medicine can make these symptoms worse); a personal or family history of tics (muscle twitches) or Tourette's syndrome; or if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, or ziprasidone.
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Is Dextroamphetamine the same as Cipralex?
It is used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy. Dextroamphetamine is also used as an athletic performance enhancer and cognitive enhancer, and has been abused for its recreational potential. Cipralex is an antidepressant belonging to a group of drugs called selective serotonin reuptake inhibitors (SSRIs). It is used to treat major depressive disorder and anxiety disorders. Cipralex increases the level of serotonin in the brain, which helps to improve mood and relieve symptoms of depression and anxiety. While dextroamphetamine and Cipralex both affect brain chemistry, they do so in different ways. Dextroamphetamine is a stimulant that increases alertness, energy levels, and focus. Cipralex is an antidepressant that balances neurotransmitter levels in order to relieve symptoms of depression and anxiety. As such, these two medications are not the same.
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What is the safest Dextroamphetamine?
It is used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy. It is also used as an athletic performance enhancer and cognitive enhancer, and has been shown to improve task completion times and reduce fatigue. Dextroamphetamine is a Schedule II controlled substance in the United States under the Controlled Substances Act. Dextroamphetamine is considered safe when used as prescribed, but there are potential side effects including insomnia, anxiety, irritability, and weight loss. When abused, dextroamphetamine can lead to addiction and other serious health problems such as cardiovascular damage and psychosis.
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